Our Company
Collaborators with synergistic skills in disease modeling, AI, bioinformatics, and drug discovery, AcuraStem's co-founders discovered PIKFYVE as a therapeutic target for ALS and FTD in a project led by co-founder Dr. Justin Ichida and published in Nature Medicine in 2018. The company has since established the iNeuroRx® technology platform, built out its team incorporating world-class antisense oligonucleotide (ASO) expertise, and established a growing pipeline of treatments.
Our Mission
We are a purpose-driven company on a mission to get our promising treatments into patients' hands as quickly as possible.
Our Values
Who We Are
AcuraStem is an LA-based biotechnology company employing cutting-edge technology in its efforts to find effective treatments for neurodegenerative diseases. AcuraStem’s team of scientists, professors, tech entrepreneurs, and successful drug company veterans are employing the latest scientific breakthroughs to address the most challenging, but we believe tractable, health problems of our time, including amyotrophic lateral sclerosis, frontotemporal dementia and other neurodegenerative indications.
Wen-Hsuan Chang, PhD – Associate Vice President, Discovery and Early Development
Dr. Wen-Hsuan Chang is an Associate Vice President, Discovery and Early Development, at AcuraStem. She leads the biology team on the NeuroRx® technology platform. Dr. Chang’s team has performed the detailed work to understand the therapeutic mechanisms underlying our drug programs, and utilizing that knowledge for clinical biomarker development. Read More.
Marcel van der Brug, Ph.D. – Chief Scientific Officer
Marcel van der Brug, Ph.D. is a seasoned neuroscientist and drug development leader, bringing extensive expertise in neurodegenerative diseases and therapeutic innovation to AcuraStem. With a robust background in neuroscience, genetics, and translational medicine, Dr. van der Brug has led scientific strategy and driven innovative solutions across multiple organizations, including Genentech. Read More.
Justin Ichida, PhD
Dr. Justin Ichida is an AcuraStem co-founder and close collaborator. He is an Associate Professor of Stem Cell Biology and Regenerative Medicine at the University of Southern California Keck School of Medicine and the Director of the Choi Therapeutic Screening Center at the Broad CIRM Center for Stem Cell Research. His major focus is in understanding cellular reprogramming and applying this approach to investigate neurological disorders. Read More.
Dan Geschwind, MD, PhD
Dr. Geschwind is the Gordon and Virginia MacDonald Distinguished Professor of Human Genetics, Neurology and Psychiatry at UCLA. His group has pioneered the application of systems biology methods in neurologic and psychiatric disease, with a focus on autism spectrum disorders and neurodegenerative conditions. Read More.
Robert Bowser, PhD
Robert Bowser, PhD, is Chief Scientific Officer, the John and Betty Van Denburgh Chair of Neuromuscular Disease, and professor and Chair of the Department of Translational Neuroscience at Barrow Neurological Institute. Dr. Bowser is an internationally recognized leader in ALS research, contributing pioneering efforts to discover and validate biomarkers for ALS and other neurodegenerative diseases. Read More.
Jeremy Shefner, MD, PhD
Jeremy Shefner, MD, PhD, is a neurologist in the Gregory W. Fulton ALS & Neuromuscular Disease Center and professor in the Department of Neurology at Barrow Neurological Institute. He is board certified in neurology by the American Board of Psychiatry and Neurology and he specializes in ALS and neuromuscular disorders. Read More.
Doug Treco, PhD
Dr. Douglas Treco is the former Chief Executive Officer and a Director of Ra Pharmaceuticals, a public biotechnology company developing treatments for complement-mediated disorders, which he founded in 2008. Ra Pharma was acquired by UCB in 2019. In 1988 Dr. Treco co-founded Transkaryotic Therapies, Inc. (TKT, acquired in 2005 by Shire plc), a multi-platform biopharmaceutical company developing protein and gene therapy products. Read More.
Careers
If you are passionate about harnessing great technology to make an impact against neurodegenerative disease, we welcome you to place your resume on file. When you join the AcuraStem team, you become part of something big.
Associate VP / Sr. Director of Translational Sciences
Partnerships
At AcuraStem, we understand that innovation doesn’t flourish in a vacuum and believe that collaborations are often the key to achieving life-altering breakthroughs. We actively engage with collaborators who are uniquely positioned to advance our mission.
